Kaplan Nursing Entrance Practice Exam 2026 – The All-in-One Guide to Exam Success!

High levels of bilirubin in the bloodstream are most closely associated with jaundice. Bilirubin is a yellow compound that is produced during the normal breakdown of red blood cells. When the liver is unable to effectively process and excrete bilirubin, either due to liver dysfunction, bile duct obstruction, or excessive breakdown of red blood cells, bilirubin builds up in the bloodstream.

This accumulation leads to the yellowing of the skin and sclera (the white part of the eyes), which are hallmark signs of jaundice. The condition serves as an important clinical indicator that indicates underlying issues such as liver disease, hemolytic anemia, or bile duct obstruction. Unlike conditions such as anemia, hemophilia, or leukemia, jaundice is specifically related to bilirubin levels and their impact on the body's appearance and overall health.